Inverse effect and receptor dynamics – Coffee, Opium and Wine's secondary pharmacology

A homeopathic widespread belief is that the inversion of effect drugs in medical practice due to dilution or very low doses, but there are many incoherencies. For example first conception similia principle was obtained through planned, small sample, clinical experiments with ponderal/pharmacological doses healthy and diseased subjects1. Furthermore classical foundations Organon2, primary secondary actions drugs, were thought be connected opposite, time-dependent reactions body high seen temporal sequence after a strong dose not changes so idea dilutions responsible for effects suitable theory. And lastly provings pathogenetic trials have frequently mixed, unregarded occasional toxicological symptoms diluted substances3, reinforcing that, on subjects, several cases substances produce same pharmacological infinitesimal doses. So at least dose-dependent generalized great part collected symptoms. Biological searched other directions4, as different sensitivity between health disease, specific, different, cell set point. In vision described here both these possibilities represent phenomenon altered sensitivity. It aim this article show original hahnemannian explain starting from biological point view ponderal seems correct, rationally comprehensible based modern knowledges. The three pharmacologic examples best illustrate reasoning, coffe, opium wine, will discussed.